During September 2017, the couple’s daughter, Grace June, was born in Nashville. In July 2021, the couple's son, James Kristoffer, was born in Miami. Ana Cristina and John Carter Cash live in Nashville with their two children. .
She recorded a full-length holiday album, My Christmas Collection, at the Cash Cabin studio. It was released in 2018. That year she provided guest vocals on heavy metal band DevilDriver's cover of "Ghost Riders in the Sky" and performed at the Johnny Cash Heritage Festival.
On 1 April 2019 she was a part of the Loretta Lynn birthday tribute show at the Bridgestone Arena in Nashville, and later that year she performed at YouTube's "Cash Fest" concert honoring Johnny Cash. On 9 November 2019 she made her Grand Ole Opry debut performing her original material. Mayor Jamie Clary of Hendersonville, Tennessee, declared 9 November "Ana Cristina Cash Day."
In 2019 a Spanish-language adaptation of Johnny Cash's "Folsom Prison Blues", co-written by Ana Cristina Cash was recorded by Los Tigres Del Norte for their prison documentary Los Tigres del Norte at Folsom Prison and the accompanying Latin Grammy-winning album.